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Pramipexole dramatically reduced the PLMS index to normal values (Wilcoxon, p=0.005). The PLMW index was also significantly reduced (Wilcoxon, p=0.007). Pramipexole also alleviated leg discomfort at bedtime and during the night as measures by the home questionnaires. Pramipexole is the most potent therapeutic agent ever tested for RLS. Measures of both sensory and motor functions returned to normal values after treatment. Moreover, these results further support the hypothesis that D3 receptors play a major role in the physiopathology of this condition. |
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